It is doubtful that while acting in D. W. Griffith's Birth of a Nation back in 1914, Lillian Gish ever dreamed that seven decades later she'd be co-starring with a cute dog in something called Hambone and Hillie. It all begins at a busy airport, where octogenarian Hillie (Gish) is accidentally separated from her beloved bow-wow Hambone. In a twinkling, Hambone and Hillie find themselves on opposite coasts of the USA. The rest of the film charts the efforts of both mistress and mutt to find each other again.
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