Timid Annie O'Keefe (Mädchen Amick) undergoes a successful heart transplant operation. While recovering, Annie undergoes a curious change in personality. The reason? It seems that the heart donor, outgoing socialite Suzanne Hawks (Monique Parent), had been murdered, and her killer is still at large. Gradually taking over Annie's brain and body, the down-but-not-out Suzanne is determined to bring her murderer to justice. Essentially a tour de force for the versatile Mädchen Amick, the made-for-cable Heartless was initially telecast by the USA network on November 5, 1997.