Bill Murray, Brandy Norwood, Chris Elliott

Inside the body of Frank there lives an entire city consisting of the body parts that make Frank work. A white blood cell cop named Osmosis Jones (Ozzy for short) teams up with by-the-book rookie cold...( read more  read more... ) tablet Drix to destroy the mysterious, evil virus that has invaded the City of Frank. Meanwhile, in the outside world, a doctor is trying to discover what is the matter with Frank.

Flixster Users

42% liked it

23,663 ratings

Critics

53% liked it

103 critics

PG, 1 hr. 28 min.

Directed by: Bobby Farrelly, Peter Farrelly

Release Date: August 10, 2001

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DVD Release Date: November 13, 2001

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Stats: 1,507 reviews

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Flixster Reviews (1,507)


  • January 25, 2009
    Good fun children's film in the spirit of 'The Fantastic Voyage'. Filled with obvious but none the less enjoyable riffs on the body systems, only the live action segments disappoint.
  • July 30, 2008
    bill murry's insides
  • July 15, 2008
    Murray's character, Frank, is the kind of Homer Simpson-esque boob whose idea of a perfect father-daughter weekend is a trip to the annual Buffalo Wing Festival. His diet consists mainly of beer, chips, and Circus Peanuts, with nary a leafy green in sight. Daughter Shane (Elena F...( read more)ranklin), appalled at her pop's careless consumption, keeps hassling the couch potato to shape up and eat right. But Frank's poor noshing habits and lazy lifestyle leave him vulnerable to illness. Intercut with the tale of Frank's sorry existence is the microscopic view inside him, which reveals a sprawling metropolis of cells, germs, and bacteria functioning under the flailing leadership of Mayor Phlemming (voiced by William Shatner). The "City of Frank" offers Jones' most rewarding comic cleverness, with numerous verbal puns related to human biology and an ample array of visual gags. Screenwriter Marc Hyman makes the most of matching each biological element and function to a real-world urban counterpart. Posters for "Peace in the Middle Ear" and "The Million Membrane March" pepper the background, and everything Frank does, from eating to peeing, involves buttons, gizmos, machinery, and the interaction of countless citizens. Nasty germs hole up in Frank's armpits, liver, and festering toes, while his stomach terminal is as busy as O'Hare Airport on Thanksgiving. Hardly thriving, the City of Frank is in disrepair and marked for destruction by the invading, nasty Red Menace, Thrax (Laurence Fishburne), who slices and burns his way through Frank's tissues with a 48-hour agenda. Only Osmosis and his straight-laced, cold-capsule partner, Drix (David Hyde Pierce), see the threat, and the two set about saving their human host from imminent death despite the Frank Police Department's universal disbelief and disdain. The idea of a man's insides being a city is a wonderfully entertaining one, with opportunities for so many jokes. We're told that the Love Handles district is "the fastest-growing community in Frank," and the mayor (William Shatner) is thrilled to announce they're about to begin construction on a third chin. The Mafia hangs out in the armpits, because that's what most closely resembles a sauna. The Farrelly brothers directed the live portions of this film, while the animated sequences were directed by Piet Kroon and Tom Sito. Personally, I enjoyed the animated sequences (which often reminded me of Space Jam) more than the live action ones, if only because there seems to be more life pumped into the drawings than the real life characters. While Bill Murray is funny, he isn't used to his full comedic extent. Still, the live-action stuff with Murray is amusing, and the animated sequences are basically entertaining, so it's not a complete waste of time.
  • March 7, 2008
    nothing to see here - move along people
  • August 14, 2007
    Really funny.
  • August 17, 2009
    it's a good diea for an animation and some of it was pretty clever but it was exicuted poorly. the animation could of been alot better. the live action pieces were not very nice to watch either which puts you off. shame really because the idea is sound
  • August 6, 2009
    It's silly but it's funny. Maybe the kids will even learn a thing or two.
  • August 1, 2009
    quirky movie.it's average enjoyed bill murray as usual.
  • June 23, 2009
    Crack kills, but someone didn't believe that and created this one anyway...
  • June 23, 2009
    SEEN IT
    REVIEW COMING SOON!

Critic Reviews


August 10, 2001
Liam Lacey, Globe and Mail

As long as Osmosis Jones sticks to the action-flick innards -- from the gangster dens of the armpits to the deportee docks of the bladder -- it's an inventive series of gags (in both senses). full review

August 10, 2001
Roger Ebert, Chicago Sun-Times

Likely to entertain kids, who seem to like jokes about anatomical plumbing. For adults, there is the exuberance of the animation and the energy of the whole movie, which is just plain clever. full review

August 9, 2001
Claudia Puig, USA Today

Adults might remain immune to the process of Osmosis, but younger viewers probably will be receptive to its nervy fun. full review

August 9, 2001
Peter Travers, Rolling Stone

Too crude for the kids and not crude enough for connoisseurs of the Something About Mary school of hair jism and balls caught in zippers, Osmosis Jones seems doomed to fall between the cracks. full review

View more Osmosis Jones reviews at RottenTomatoes.com

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Osmosis Jones Trivia


  • In Osmosis Jones, what did Frank eat to make him vomit?  Answer »
  • Which 'Frasier' actor played an animated cold pill in 2001's 'Osmosis Jones'?  Answer »
  • Which movie has this tagline : " Every Body Needs A Hero " ?  Answer »
  • What did Osmosis Jones call Drix in the movie Osmosis Jones?  Answer »

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