The stars of Shoot to Kill are Douglas Blackley and Susan Walters, both of whom later changed their professional names to, respectively, Robert Kent and Luana Walters. Blackley is a gangster who is framed by crooked DA Edmund MacDonald. Walters, Blackley's wife, secures a job as MacDonald's assistant, the better to find the proof of the DA's dishonesty. Reporter Russell Wade helps Walters expose MacDonald, falling in love with her along the way. The film is related in flashback by Walters, who lies hovering between life and death in a hospital bed.