SIX is a martial arts action thriller enveloped in Manga trappings. A mad scientist has successfully created five hybrids by fusing human and animal genes together, granting them animal-like capabilities that allow them to fight fiercely. The five must join together when another of their kind known only as SIX intends to hunt them down and harness their powers. A lethal game of hide-and-seek soon begins, driven by the emotional journey between these compelling characters that are also romantically entangled. At the final showdown, the secret of SIX is revealed.