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Cast

• Gary Cooper
  as Lou Gehrig
• Teresa Wright
  as Eleanor Gehrig
• George Herman "Babe" Ruth
  as Himself
• Walter Brennan
  as Sam Blake
• Dan Duryea
  as Hank Hanneman
• Elsa Janssen
  as Mrs. Gehrig
• Ludwig Stossel
  as Pop Gehrig
• Virginia Gilmore
  as Myra
• Bill Dickey
  as Himself
• Ernie S. Adams
  as Miller Huggins
• Pierre Watkin
  as Mr. Twitchell
• Mark Koenig
  as Himself
• Bill Stern
  as Himself
• Addison Richards
  as Coach
• Hardie Albright
  as Van Tuyl
• Edward Fielding
  as Clinic Doctor
• George Lessey
  as Mayor of New Rochelle
• Douglas Croft
  as Lou Gehrig as a Boy
• Edgar Barrier
  as Hospital Doctor
• Anita Bolster
  as Sasha's Mother
• Lane Chandler
  as Player in Locker Room
• Bill Chaney
  as Newsboy
• Janet Chapman
  as Tessie
• Spencer Charters
  as Mr. Larsen
• Dane Clark
  as Fraternity Boy
• Gene Collins
  as Billy
• Eva Dennison
  as Mrs. Worthington
• Frank Faylen
  as Yankee
• Pat Flaherty
  as Baseball Player
• Vaughan Glaser
  as Doctor in Gehrig Home
• Mary Gordon
  as Maid
• Harry Harvey
  as Joe McCarthy
• Vinton Haworth
• David Holt
  as Billy at 17
• John Kellogg
  as Fraternity Boy
• David Manley
  as Mayor Fiorello LaGuardia
• George McDonald
  as Wally Pip
• Matt McHugh
  as Strength Machine Operator
• Robert W. Meusel
  as Himself
• Tom Neal
  as Fraternity Boy
• Patsy O'Byrne
  as Scrubwoman
• Sarah Padden
  as Mrs. Robert
• Ray Noble and Orchestra
• Billy Roy
  as Joe Fabini
• C. Montague Shaw
  as Mr. Worthington
• Dorothy Vaughan
  as Landlady
• Veloz & Yolanda
  as Specialty Dancer
• Max Willenz
  as Colletti
• Jack Shea
  as Hammond
• Jack Stewart
  as Ed Burrow
• Ted Offenbecker
  as Freshman
• Robert Winkler
  as Murphy
• Lorna Dunn
  as Clinic Nurse
• Rosina Galli
  as Mrs. Fabini
• Babe Ruth

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